Conditions

Understanding Erythromelalgia

Erythromelalgia (EM) — sometimes called burning feet syndrome — is a rare and chronic condition characterised by episodes of intense burning pain, redness, warmth, and swelling of the skin, most commonly affecting the feet and sometimes the hands, legs, or other regions. 

The term “erythromelalgia” comes from Greek: erythros (red), melos (limb), and algia (pain). 

This condition involves a mixture of neurovascular dysfunction — abnormalities in small blood vessels (microvasculature) and nerve pathways (especially small-fiber nerves) — leading to abnormal blood flow, heat, and pain.

Wessex Pain Clinic

How We Diagnose

Diagnosis is primarily clinical and relies on the characteristic pattern of symptoms, along with exclusion of other conditions. There is no definitive single test. 

Key diagnostic considerations include:

  • Typical symptoms: burning pain, warmth or heat, skin redness during flares, sometimes swelling or sweating changes. 
  • Triggering factors: heat, exertion, dependency (legs lowered), tight footwear or clothing may worsen flares. Symptoms are often amplified by stress.
  • Pattern & distribution: often bilateral in the feet, but can affect hands, arms or face; flares may last minutes to days. 
  • Associated causes (in “secondary” cases): blood disorders (e.g. myeloproliferative disorders), autoimmune disease, neuropathy, vascular disease. 

Because EM is rare and often misdiagnosed, specialist assessment is crucial.

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Lifestyle and Complementary Therapies

Because triggers play a large role in flares, self-management is key:

  • Avoiding triggers: Heat, tight clothing or footwear, strenuous exercise, spicy foods, stress, or alcohol may precipitate flares.
  • Loose clothing, good footwear, avoiding compression.
  • Hydration and skin care to protect vulnerable skin.
  • Psychological support: Given the severe pain, anxiety, isolation or frustration may arise; cognitive behavioural therapy, mindfulness and pacing strategies can help.

At Wessex Pain Clinic, we work as a team and meet regularly to discuss complex, treatment resistant or unusual cases. As such you will often receive the expertise of several pain consultants. We believe that we are one of very few pain clinics to offer this.

Medications & Medical Therapy
  • Sodium channel blockers: In some primary cases, drugs such as mexiletine or other agents targeting sodium channels may be beneficial.
  • Vasodilators / vascular modulators.
  • Topical treatments: Capsaicin creams, lidocaine patches, or other local analgesics may soothe superficial nerve irritation.
  • Pain control / neuropathic agents: Drugs such as gabapentin, pregabalin, or certain antidepressants may assist in dampening nerve hyperexcitability during flares. 
Interventional Procedures

Where symptoms are refractory, we may offer:

  • Intravenous infusions (e.g. lidocaine, prostaglandins) in hospital settings to calm flares.

Management of erythromelalgia is challenging but can be significantly helped by a tailored, multidisciplinary approach. Treatment aims to reduce frequency and severity of flares, manage pain, and address underlying causes where present.

Treatment at Wessex Pain Clinic

Treatments