Piriformis / Deep Gluteal Injection

Wessex Pain Clinic

Piriformis / Deep Gluteal Injection

Piriformis or deep gluteal injections are used to treat pain originating from the muscles and nerves in the buttock region. These image-guided injections target the piriformis muscle or nearby deep gluteal structures and may involve a combination of local anaesthetic and steroid, or — in selected cases — botulinum toxin (Botox) to reduce muscle spasm and nerve compression.

How the Procedure Works

The piriformis muscle lies deep in the buttock and runs from the sacrum to the hip. The sciatic nerve passes either under or through this muscle. When the piriformis or other deep gluteal muscles become tight, inflamed, or hypertrophied, they can compress the sciatic nerve — a condition known as piriformis syndrome or part of the deep gluteal syndrome spectrum.

Under ultrasound or fluoroscopic guidance, your consultant inserts a fine needle into the targeted muscle or fascial plane. The injection may contain:

Local anaesthetic and corticosteroid: to reduce inflammation and provide temporary pain relief

Botulinum toxin (Botox): in selected cases, to reduce sustained muscle tension or spasm contributing to nerve compression

Botulinum toxin acts by temporarily relaxing the muscle, allowing the sciatic nerve to move more freely and reducing irritation.

Wessex Pain Clinic

What Conditions It Can Help With

These injections may be suitable for:
Piriformis syndrome
Deep gluteal syndrome (nerve entrapment in the buttock)
Referred sciatic-type leg pain not originating from the spine
Gluteal pain following trauma or overuse
Post-surgical nerve entrapment or scarring in the deep gluteal region

The treatment may also help clarify whether the pain is muscular or nerve-related.

Aimed Benefits

The injection is designed to:
Reduce muscle tension and inflammation in the deep gluteal region
Relieve buttock or sciatic-type pain
Improve sitting tolerance and mobility
Support participation in physiotherapy or rehabilitation
Guide further care based on diagnostic response

The treatment may also help clarify whether the pain is muscular or nerve-related.

What to Expect

This is an outpatient procedure, typically lasting 20–30 minutes. You’ll lie on your stomach while the skin is cleaned and numbed. Your consultant uses ultrasound or X-ray guidance to place the needle precisely into the piriformis or relevant deep gluteal muscle.

The injection itself is usually well tolerated. If botulinum toxin is used, the full benefit may take a few weeks to develop. Patients go home the same day and are advised to rest briefly before gradually increasing activity as guided.

Risks and Considerations

All procedures carry some risks, which will be discussed in detail with you during your consultation. You will have the opportunity to ask questions, and formal consent will always be obtained before any procedure is carried out.

Combined Approach / Multidisciplinary Care

At Wessex Pain Clinic we find that the best results come from combining medical treatments with active rehabilitation. Procedures are often most effective when paired with physiotherapy, movement-based exercise, and — where appropriate — psychological support. This comprehensive approach addresses both the physical and emotional aspects of pain and supports longer-term improvement.

Key Points Summary

  • Consultant-led injection into the piriformis or deep gluteal muscles
  • Uses local anaesthetic/steroid or botulinum toxin (Botox), depending on presentation
  • Aims to reduce muscle spasm and relieve sciatic-type pain
  • Image-guided for precision and safety
  • Can support diagnosis and rehabilitation

Disclaimer

Results vary between individuals and cannot be guaranteed. Your consultant will discuss whether this procedure is appropriate for you.

At Wessex Pain Clinic, we work as a team and meet regularly to discuss complex, treatment resistant or unusual cases. As such you will often receive the expertise of several pain consultants. We believe that we are one of very few pain clinics to offer this.

Driving advice: You should not drive that day if receiving any sedation. Our procedures do vary on whether they are possible to drive home from yourself, please seek advice from your consultant about driving advice. If you are seeing us for an injection and planning on driving, please check with us beforehand about whether it will be possible to drive yourself home afterwards.

Wessex Pain Clinic provides consultant-led assessment and treatment for acute and chronic pain conditions. Our multidisciplinary team includes Consultant Pain Specialists, Physiotherapists and Psychologists, offering evidence-based interventions alongside rehabilitation and self-management support. We welcome patients from across Hampshire, Dorset, Wiltshire, Surrey and Sussex, including Winchester, Basingstoke, Southampton, Portsmouth, and Chichester – with both in-clinic appointments and remote consultations available across the wider Wessex region.